Detaillierte Hinweise zur Behandlung von Opioidsucht
Detaillierte Hinweise zur Behandlung von Opioidsucht
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Patients should be cautioned that methadone, like other opioids, may produce orthostatic hypotension in ambulatory patients.
Methadone should be given with caution and the initial dose reduced rein certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.
Don’t put this medication hinein your car’s glove compartment or leave it hinein the car. Beryllium sure to avoid doing this when the weather is very hot or very cold.
Opioide sind sowohl körpereigene als sogar natürliche sowie synthetisch hergestellte Substanzen die an den Opioidrezeptoren wirken. Es handelt umherwandern am werk um eine morphinartige Betätigung, die direktemang zur Sucht führen kann.
Rein the selection of an initial dose of methadone hydrochloride tablets, attention should be given to the following:
Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most bekannt of which involves the central nervous Struktur and organs composed of smooth muscle.
Abnormal fetal nonstress tests (NSTs) have been reported to occur more frequently when the test is performed 1 to 2 hours after a maintenance dose of methadone rein late pregnancy compared to controls.
The complexities associated with methadone dosing can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration. A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise.
Failure to abide by the requirements rein these regulations may result hinein criminal prosecution, seizure of the drug supply, revocation of the program approval, and injunction precluding operation of the program.
Laxatives. Taking these drugs together can change Methadontabletten 10 mg online your electrolyte levels. This can cause heart rhythm problems.
The decrease in plasma half-life and increased clearance of methadone resulting rein lower methadone trough levels during pregnancy can lead to withdrawal symptoms rein some pregnant patients. The dosage may need to Beryllium increased or the dosing interval decreased in pregnant patients receiving methadone (Teich PRECAUTIONS, Pregnancy, Labor and Delivery, and DOSAGE AND ADMINISTRATION).
A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise. Respiratory depression is of particular concern rein elderly or debilitated patients as well as hinein those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.
The relative potency estimate used to calculate an equianalgesic starting methadone dose, in particular, whether it is intended for use hinein acute or chronic methadone dosing;
Primary attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. If a non-tolerant person, takes a large dose of methadone, effective opioid antagonists are available to counteract the potentially lethal respiratory depression. The physician must remember, however, that methadone is a long-acting depressant (36 to 48 hours), whereas opioid antagonists act for much shorter periods (one to three hours).